Proto-Oncogene Ets-1 and the Kidney
نویسندگان
چکیده
منابع مشابه
Proto-oncogene Ets-1 and the kidney.
Most forms of advanced glomerular diseases, if not all, are characterized by abnormal turnover of extracellular matrix (ECM) proteins in glomeruli, resulting in structural alterations of glomerular basement membrane and mesangial matrix, usually leading to proteinuria. It is, therefore, important to elucidate the regulatory mechanisms of ECM metabolism in glomerular diseases. Various types of c...
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The proto-oncogene Ets-1 is a transcription factor that is known to regulate certain matrix metalloproteinases and plasminogen activator, which have been associated with malignant behaviors in solid carcinomas. We hypothesized that Ets-1 expression is also associated with tumor progression and a worse prognosis in lung carcinoma patients. To clarify the role of the Ets-1 proto-oncogene, the exp...
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BACKGROUND Ets-1 proto-oncogene exhibits multiple activities in the transcriptional regulation of numerous genes including metalloproteinase (MMP)-1, -3 and -9. MMPs play an important role in the remodelling of extracellular matrix in various renal diseases. However, the role of the Ets-1-MMP axis in advanced renal diseases is uncertain. In the present study, we investigated whether Ets-1 is in...
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Many of the Ets proteins have been shown to be transcription activators. In vitro, Ets 1 proteins are involved in the transcriptional induction of genes such as stromelysin 1, collagenase 1 or urokinase type plasminogen activator, which are proteases responsible for extracellular matrix degradation. In vivo, c-ets 1 is expressed in a wide variety of embryonic tissues in migrating cells, especia...
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Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. Associations between specific RET mutations (genotype) and the aggressiveness of MTC and presence or absence of other endocrine neoplasms (phenotype) are well documented. Mutations in six exons (10, 11, 13, 14, 15, and 16) located in either cysteine-rich or tyrosine...
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ژورنال
عنوان ژورنال: Nephron
سال: 2001
ISSN: 1660-8151,2235-3186
DOI: 10.1159/000046034